More than half of people taking common antidepressants report experiencing significant sexual side effects, including a lowered sex drive and difficulty enjoying sex, according to new research from sexual wellness brand Lovehoney.
The Scale of the Issue
The study, published on 30 November 2025, found that these medication side effects have led to 40% of users having less sex. A major contributing factor is that many people are unaware that sexual problems are a potential side effect of their treatment.
Compounding the issue, the research indicates that users often feel too uncomfortable to discuss these intimate concerns with their partners, family, or even their GP.
With approximately one in six adults in England – equating to 8.89 million people – currently prescribed antidepressants, this means an estimated over 4.6 million individuals could be experiencing reduced sexual desire as part of their treatment.
Understanding the Causes and Seasonal Trends
These symptoms are common across various types of antidepressants and anti-anxiety medications. The research was released during November and December, a period when prescriptions for antidepressants typically increase due to seasonal affective disorder (SAD) and winter-related low mood.
Dr Anand Patel, a GP and men's health expert, explained the biological mechanism behind these effects: "Antidepressants work by boosting serotonin levels, which can help lift mood and ease anxiety. But serotonin can also slow down the brain's arousal and reward systems, meaning reduced desire, dulled pleasure and delayed orgasm."
Interestingly, the study also revealed a contrasting finding: 22% of respondents reported an increase in their libido while on medication.
Managing and Overcoming Side Effects
Dr Patel emphasised that there is hope for those affected. "The good news is that for most people, these effects are temporary and manageable. With the right medical support - such as dose adjustments, medication changes or therapy - sexual wellbeing can absolutely be restored."
He strongly advised patients not to suffer in silence: "No one should feel embarrassed bringing this up with their doctor. A simple conversation can make a big difference."
For those uncertain about how to start this conversation, Dr Patel suggests being direct with your GP: "You can simply say, 'I've noticed some changes in my sex drive since starting this medication, is that something we can talk about?'"
He also recommends asking specific questions when first prescribed antidepressants, including:
- "How likely is this medication to affect my sex drive?"
- "Are there alternatives?"
- "If I notice changes, what should I do?"
For those preferring to explore lifestyle changes first, Dr Patel noted that regular exercise, good sleep, stress management, mindfulness, and relationship therapy can all help improve libido while continuing antidepressant treatment.
He also highlighted that some antidepressants have a much lower incidence of sexual side effects, citing mirtazapine, which only affects 1-2% of people, and escitalopram, which affects 5-10%.
Individuals seeking further guidance are encouraged to visit the NHS website for information or speak directly with their healthcare provider.
